All posts by mylifeteam

Naltrexone implant for the Treatment of Polydrug Dependence: A randomized Controlled Trial

From  Am  J  Psychiatry  2012;  169:531–536
By: Jari Tiihonen, M.D., Ph.D. Evgeny Krupitsky, M.D., Ph.D. Elena, Verbitskaya, Ph.D. Elena Blokhina, M.D., Ph.D. Olga Mamontova, M.D., Jaana Föhr, M.D., Pekka Tuomola, M.D., Ph.D., Kimmo Kuoppasalmi, M.D., Ph.D., Vesa Kiviniemi, Ph.D. Edwin Zwartau, M.D., Ph.D

Objective: The majority of drug addicts are polydrug dependent, and no effective pharmacological treatment is currently available for them. The authors studied the overall real-world effectiveness of naltrexone implant in this patient population.

Method: The authors assessed the effectiveness of a naltrexone implant in the treatment of coexisting heroin and amphetamine polydrug dependence in 100 heroin- and amphetamine-dependent outpatients in a 10-week randomized, double-blind, placebo-controlled trial. The main outcome measures were retention in the study, proportion of drug-free urine samples, and improvement score on the Clinical Global Impressions Scale (CGI). Analyses were conducted in an in- tent-to-treat model.

Results: At week 10, the retention rate was 52% for patients who received a naltrexone implant and 28% for those who received a placebo implant; the proportions of drug-free urine samples were 38% and 16%, respectively, for the two groups. On the CGI improvement item, 56% of the patients in the naltrexone group showed much or very much improvement, com- pared with 14% of those in the placebo group (number needed to treat=3).

Conclusions: Naltrexone implants resulted in higher retention in the study, decreased heroin and amphetamine use, and improved clinical condition for patients, thus providing the first evidence of an effective pharmacological treatment for this type of polydrug dependence.

For more information on the benefits of naltrexone implant, read the original article here.


What’s the Answer to Substance Abuse?

Dan M. Asimus M.D., M.S.Ed

Alcohol and drug abuse is an international epidemic blazing out of control. Many individuals and families have been so traumatized by its effects. Often it begins innocently and then addiction gets its grip and begins to injure and destroy lives and those around them. Approximately 53% of adults in the United States have reported that one or more of their close relatives has a drinking problem. But, what are the solutions? Why is the epidemic occurring? Why is the relapse rate so high? What are we missing? Continue reading

Wall Street Journal: A Prescription to End Drinking


New understanding of how alcohol affects the brain is prompting addiction experts to make a push for using medications to help people quit or cut down on excessive drinking.
For years, treatment has meant 28 days of rehab or a 12-step program. Success meant total abstinence. Only 1 in 10 of the 17 million Americans with a drinking problem ever tried.

The Economist Explains Why Heroin Has Made A Comeback in America


HEROIN was a scourge of America’s cities in the 1960s and 70s. But then it seemed to go out of fashion. By the 1990s it was less widely used than crack cocaine. In Europe its use has continued to decline, with the number of addicts falling by about one-third in the past decade. In America, by contrast, it is resurgent. Last year nearly 700,000 Americans took the drug, twice as many as a decade ago. It is now more popular than crack, by some measures. What explains heroin’s return?


Drugs to Aid Alcoholics See Little Use, Study Finds

Naltrexone Implant treatment


Two medications could help tens of thousands of alcoholics quit drinking, yet the drugs are rarely prescribed to patients, researchers reported…

“It’s been a slow transition getting these medications onto the medical agenda,” she said. “But patients need to know that addiction is a biological condition of the brain and that we have treatments to improve it.”